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KMID : 0928320080080020108
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Korean Journal of Health Promotion and Disease Prevention
2008 Volume.8 No. 2 p.108 ~ p.116
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Relationship between Urinary Phenol and TBARS Concentrations According to the ALDH2 and PON1 Genotypes
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Lee Chul-Ho
Eom Sang-Yong
Kim Yong-Dae
Yu Seung-Do
Kim Heon
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Abstract
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Background: This study was performed to test the relationship between the levels of phenol and thiobarbituric acid reactive substance (TBARS) in urines from individuals who were not occupationally exposed to benzene, and to evaluate the effects of ALDH2 gene and PON1 gene polymorphism on the relationship.
Method: One hundred and fifty-five persons (89 males and 66 females) who visited a university hospital for a screening test and were not occupationally exposed to benzene were the subjects of this study. Information about smoking status was collected through interviews. Urinary phenol and TBARS concentrations were measured, and genotypes of ALDH2 and PON1 genes were identified. Urinary phenol and TBARS levels were compared according to sex, smoking status and the ALDH2 and PON1 genotypes. The correlation between ln(phenol) and ln(TBARS) was statistically tested in all subjects and in subgroups with different ALDH2 and PON1 genotypes.
Results: Urinary phenol and TBARS concentrations were higher in females than in males, but no statistical difference was found in the comparisons according to sex, smoking status, and the ALDH2 and PON1 genotypes. There was a signigicant correlation between ln(phenol) and ln(TBARS), and especially in males, non-smokers or individuals with ALDH2 *1/*1 or PON1 Q/R genotype. Those with ALDH2 *1/*1 genotype and PON1 Q/Q or Q/R genotype showed a higher and significant correlation between between the natural logarithmic values of urinary phenol and TBARS concentrations.
Conclusions: An increase in urinary phenol concentration leads to a more severe lipid peroxidation or oxidative stress. Individuals with ALDH2 *1/*1 genotype and PON1 Q/Q or Q/R genotype would be more sensitive to the phenol-related lipid peroxidation.
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KEYWORD
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phenol, TBARS, ALDH2, PON1
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